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GENERAL
TITLE
CRYSTAL STRUCTURE OF MACROCYCLIC PROTAC 1 IN COMPLEX WITH THE SECOND BROMODOMAIN OF HUMAN BRD4 AND PVHL:ELONGINC:ELONGINB
DATE LAST MODIFIED
29 Jan 2020
RELEASE
4 Dec 2019
OBSOLETE
CLASSIFICATION
LIGASE
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 32
RESOLUTION RANGE HIGH
3.5
RESOLUTION RANGE LOW
49.73
PUBMED ID
DOI
10.1002/ANIE.201914396
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
O60885 BRD4, HUNK1 ESCHERICHIA COLI BL21(DE3) HUMAN
PROTEIN HUNK1
Mutations
Q15370 ELOB, TCEB2 ESCHERICHIA COLI BL21(DE3) HUMAN
ELOB,ELONGIN 18 KDA SUBUNIT,RNA POLYMERASE II TRAN ...
Mutations
Q15369 ELOC, TCEB1 ESCHERICHIA COLI BL21(DE3) HUMAN
ELOC,ELONGIN 15 KDA SUBUNIT,RNA POLYMERASE II TRAN ...
Mutations
P40337 VHL ESCHERICHIA COLI BL21(DE3) HUMAN
PROTEIN G7,PVHL
Mutations
O60885 BRD4, HUNK1 ESCHERICHIA COLI BL21(DE3) HUMAN
PROTEIN HUNK1
Mutations
Q15370 ELOB, TCEB2 ESCHERICHIA COLI BL21(DE3) HUMAN
ELOB,ELONGIN 18 KDA SUBUNIT,RNA POLYMERASE II TRAN ...
Mutations
Q15369 ELOC, TCEB1 ESCHERICHIA COLI BL21(DE3) HUMAN
ELOC,ELONGIN 15 KDA SUBUNIT,RNA POLYMERASE II TRAN ...
Mutations
P40337 VHL ESCHERICHIA COLI BL21(DE3) HUMAN
PROTEIN G7,PVHL
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402