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GENERAL
TITLE
STRUCTURAL INSIGHTS INTO MYCOBACTERIUM TUBERCULOSIS CLPP1P2 INHIBITION BY CEDIRANIB: IMPLICATIONS FOR DEVELOPING ANTIMICROBIAL AGENTS TARGETING CLP PROTEASE
DATE LAST MODIFIED
29 Apr 2020
RELEASE
1 Jan 2020
OBSOLETE
CLASSIFICATION
HYDROLASE/HYDROLASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
C 1 2 1
RESOLUTION RANGE HIGH
2.69
RESOLUTION RANGE LOW
30
PUBMED ID
-
DOI
--
LIGANDS
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Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
P9WPC2 CLPP2, MT2535 ESCHERICHIA COLI BL21(DE3) MYCOBACTERIUM TUBERCULOSIS CDC1551
ENDOPEPTIDASE CLP 2
Mutations
P9WPC4 CLPP1, CLPP, MT2536 ESCHERICHIA COLI BL21(DE3) MYCOBACTERIUM TUBERCULOSIS CDC1551
ENDOPEPTIDASE CLP 1
Mutations
P9WPC2 CLPP2, MT2535 ESCHERICHIA COLI BL21(DE3) MYCOBACTERIUM TUBERCULOSIS CDC1551
ENDOPEPTIDASE CLP 2
Mutations
P9WPC4 CLPP1, CLPP, MT2536 ESCHERICHIA COLI BL21(DE3) MYCOBACTERIUM TUBERCULOSIS CDC1551
ENDOPEPTIDASE CLP 1
Mutations
P9WPC2 CLPP2, MT2535 ESCHERICHIA COLI BL21(DE3) MYCOBACTERIUM TUBERCULOSIS CDC1551
ENDOPEPTIDASE CLP 2
Mutations
P9WPC2 CLPP2, MT2535 ESCHERICHIA COLI BL21(DE3) MYCOBACTERIUM TUBERCULOSIS CDC1551
ENDOPEPTIDASE CLP 2
Mutations
P9WPC4 CLPP1, CLPP, MT2536 ESCHERICHIA COLI BL21(DE3) MYCOBACTERIUM TUBERCULOSIS CDC1551
ENDOPEPTIDASE CLP 1
Mutations
P9WPC2 CLPP2, MT2535 ESCHERICHIA COLI BL21(DE3) MYCOBACTERIUM TUBERCULOSIS CDC1551
ENDOPEPTIDASE CLP 2
Mutations
P9WPC4 CLPP1, CLPP, MT2536 ESCHERICHIA COLI BL21(DE3) MYCOBACTERIUM TUBERCULOSIS CDC1551
ENDOPEPTIDASE CLP 1
Mutations
P9WPC2 CLPP2, MT2535 ESCHERICHIA COLI BL21(DE3) MYCOBACTERIUM TUBERCULOSIS CDC1551
ENDOPEPTIDASE CLP 2
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402