5WEV logo

5WEV

3D Structure View

Loading...

More Info

GENERAL
TITLE
IDENTIFICATION OF AN IMIDAZOPYRIDINE SCAFFOLD TO GENERATE POTENT AND SELECTIVE TYK2 INHIBITORS THAT DEMONSTRATE ACTIVITY IN AN IN VIVO PSORIASIS MODEL
DATE LAST MODIFIED
20 Sept 2017
RELEASE
6 Sept 2017
OBSOLETE
CLASSIFICATION
TRANSFERASE/TRANSFERASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
C 1 2 1
RESOLUTION RANGE HIGH
1.85
RESOLUTION RANGE LOW
50.01
PUBMED ID
DOI
10.1016/J.BMCL.2017.08.022

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
O60674 JAK2 UNIDENTIFIED BACULOVIRUS HUMAN
JANUS KINASE 2,JAK-2
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402