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GENERAL
TITLE
CRYSTAL STRUCTURE OF 11BETA-HSD1 DOUBLE MUTANT (L262R, F278E) COMPLEXED WITH 2-(2-BENZYL-6-HYDROXYADAMANTAN-2-YL)-1-(3- HYDROXYAZETIDIN-1-YL)ETHAN-1-ONE
DATE LAST MODIFIED
21 Feb 2018
RELEASE
1 Nov 2017
OBSOLETE
CLASSIFICATION
OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 21 21 21
RESOLUTION RANGE HIGH
2.5
RESOLUTION RANGE LOW
50
PUBMED ID
DOI
10.1021/ACS.JMEDCHEM.7B00211
PDBe
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Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
P28845 HSD11B1, HSD11, HSD11L, SDR26C1 ESCHERICHIA COLI HUMAN
11-BETA-HYDROXYSTEROID DEHYDROGENASE 1,11-BETA-HSD ...
Mutations
P28845 HSD11B1, HSD11, HSD11L, SDR26C1 ESCHERICHIA COLI HUMAN
11-BETA-HYDROXYSTEROID DEHYDROGENASE 1,11-BETA-HSD ...
Mutations
P28845 HSD11B1, HSD11, HSD11L, SDR26C1 ESCHERICHIA COLI HUMAN
11-BETA-HYDROXYSTEROID DEHYDROGENASE 1,11-BETA-HSD ...
Mutations
P28845 HSD11B1, HSD11, HSD11L, SDR26C1 ESCHERICHIA COLI HUMAN
11-BETA-HYDROXYSTEROID DEHYDROGENASE 1,11-BETA-HSD ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402