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GENERAL
TITLE
BRAIN PENETRANT LIVER X RECEPTOR (LXR) MODULATORS BASED ON A 2,4,5,6- TETRAHYDROPYRROLO[3,4-C]PYRAZOLE CORE
DATE LAST MODIFIED
1 Nov 2017
RELEASE
21 Sept 2016
OBSOLETE
CLASSIFICATION
DNA BINDING PROTEIN
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 21 21 21
RESOLUTION RANGE HIGH
2.598
RESOLUTION RANGE LOW
44.48
PUBMED ID
DOI
10.1016/J.BMCL.2016.08.089
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
P55055 NR1H2, LXRB, NER, UNR ESCHERICHIA COLI HUMAN
LIVER X RECEPTOR BETA,NUCLEAR RECEPTOR NER,NUCLEAR ...
Mutations
P28702 RXRB, NR2B2 ESCHERICHIA COLI HUMAN
NUCLEAR RECEPTOR SUBFAMILY 2 GROUP B MEMBER 2,RETI ...
Mutations
P55055 NR1H2, LXRB, NER, UNR ESCHERICHIA COLI HUMAN
LIVER X RECEPTOR BETA,NUCLEAR RECEPTOR NER,NUCLEAR ...
Mutations
P28702 RXRB, NR2B2 ESCHERICHIA COLI HUMAN
NUCLEAR RECEPTOR SUBFAMILY 2 GROUP B MEMBER 2,RETI ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402