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GENERAL
TITLE
DISCOVERY OF IMIDAZOQUINOLINES AS A NOVEL CLASS OF POTENT, SELECTIVE AND IN VIVO EFFICACIOUS COT KINASE INHIBITORS
DATE LAST MODIFIED
7 Sept 2016
RELEASE
24 Aug 2016
OBSOLETE
CLASSIFICATION
TRANSFERASE
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 2 21 21
RESOLUTION RANGE HIGH
2.7
RESOLUTION RANGE LOW
71.66
PUBMED ID
DOI
10.1021/ACS.JMEDCHEM.6B00598
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
P41279 -- -- HUMAN
CANCER OSAKA THYROID ONCOGENE,PROTO-ONCOGENE C-COT ...
Mutations
P41279 -- -- HUMAN
CANCER OSAKA THYROID ONCOGENE,PROTO-ONCOGENE C-COT ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402