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5HG8

3D Structure View

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GENERAL
TITLE
EGFR (L858R, T790M, V948R) IN COMPLEX WITH N-[3-({2-[(1-METHYL-1H- PYRAZOL-4-YL)AMINO]-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL}OXY)PHENYL]PROP- 2-ENAMIDE
DATE LAST MODIFIED
22 Nov 2017
RELEASE
3 Feb 2016
OBSOLETE
CLASSIFICATION
TRANSFERASE/TRANSFERASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 21 21 21
RESOLUTION RANGE HIGH
1.42
RESOLUTION RANGE LOW
58.99
PUBMED ID
DOI
10.1021/ACS.JMEDCHEM.5B01633

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
P00533 EGFR, ERBB, ERBB1, HER1 SPODOPTERA FRUGIPERDA HUMAN
PROTO-ONCOGENE C-ERBB-1,RECEPTOR TYROSINE-PROTEIN ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402