5HG7 logo

5HG7

3D Structure View

Loading...

More Info

GENERAL
TITLE
EGFR (L858R, T790M, V948R) IN COMPLEX WITH 1-{(3R,4R)-3-[5-CHLORO-2- (1-METHYL-1H-PYRAZOL-4-YLAMINO)-7H-PYRROLO[2,3-D]PYRIMIDIN-4- YLOXYMETHYL]-4-METHOXY-PYRROLIDIN-1-YL}PROPENONE (PF-06459988)
DATE LAST MODIFIED
23 Mar 2016
RELEASE
27 Jan 2016
OBSOLETE
CLASSIFICATION
TRANSFERASE/TRANSFERASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 21 21 21
RESOLUTION RANGE HIGH
1.83
RESOLUTION RANGE LOW
59.49
PUBMED ID
DOI
10.1021/ACS.JMEDCHEM.5B01633

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
P00533 EGFR, ERBB, ERBB1, HER1 SPODOPTERA FRUGIPERDA HUMAN
PROTO-ONCOGENE C-ERBB-1,RECEPTOR TYROSINE-PROTEIN ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402