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GENERAL
TITLE
A TRIPLE MUTANT IN THE OMEGA-LOOP OF TEM-1 BETA-LACTAMASE CHANGES THE SUBSTRATE PROFILE VIA A LARGE CONFORMATIONAL CHANGE AND AN ALTERED GENERAL BASE FOR CATALYSIS
DATE LAST MODIFIED
6 May 2015
RELEASE
4 Mar 2015
OBSOLETE
CLASSIFICATION
HYDROLASE
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 1
RESOLUTION RANGE HIGH
2.31
RESOLUTION RANGE LOW
62.89
PUBMED ID
DOI
10.1074/JBC.M114.633438
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
Q02127 BLA, BLAT-3, BLAT-4, BLAT-5, BLAT-6 ESCHERICHIA COLI ESCHERICHIA COLI
IRT-4, PENICILLINASE, TEM-1, TEM-16/CAZ-7, TEM-2, ...
O15085 BLA, BLAT-3, BLAT-4, BLAT-5, BLAT-6 ESCHERICHIA COLI ESCHERICHIA COLI
IRT-4, PENICILLINASE, TEM-1, TEM-16/CAZ-7, TEM-2, ...
P62593 BLA, BLAT-3, BLAT-4, BLAT-5, BLAT-6 ESCHERICHIA COLI ESCHERICHIA COLI
IRT-4, PENICILLINASE, TEM-1, TEM-16/CAZ-7, TEM-2, ...
Mutations
P62593 BLA, BLAT-3, BLAT-4, BLAT-5, BLAT-6 ESCHERICHIA COLI ESCHERICHIA COLI
IRT-4, PENICILLINASE, TEM-1, TEM-16/CAZ-7, TEM-2, ...
Mutations
P08134 BLA, BLAT-3, BLAT-4, BLAT-5, BLAT-6 ESCHERICHIA COLI ESCHERICHIA COLI
IRT-4, PENICILLINASE, TEM-1, TEM-16/CAZ-7, TEM-2, ...
O15085 BLA, BLAT-3, BLAT-4, BLAT-5, BLAT-6 ESCHERICHIA COLI ESCHERICHIA COLI
IRT-4, PENICILLINASE, TEM-1, TEM-16/CAZ-7, TEM-2, ...
P62593 BLA, BLAT-3, BLAT-4, BLAT-5, BLAT-6 ESCHERICHIA COLI ESCHERICHIA COLI
IRT-4, PENICILLINASE, TEM-1, TEM-16/CAZ-7, TEM-2, ...
Mutations
P08134 BLA, BLAT-3, BLAT-4, BLAT-5, BLAT-6 ESCHERICHIA COLI ESCHERICHIA COLI
IRT-4, PENICILLINASE, TEM-1, TEM-16/CAZ-7, TEM-2, ...
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402