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GENERAL
TITLE
ITK KINASE DOMAIN WITH COMPOUND 27 (N-{1-[(1R)-3-(DIMETHYLAMINO)-1- PHENYLPROPYL]-1H-PYRAZOL-4-YL}-6-(1H-PYRAZOL-4-YL)-1H-INDAZOLE-3- CARBOXAMIDE)
DATE LAST MODIFIED
31 Jan 2018
RELEASE
4 Jun 2014
OBSOLETE
CLASSIFICATION
TRANSFERASE/TRANSFERASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 21 21 21
RESOLUTION RANGE HIGH
2.95
RESOLUTION RANGE LOW
55.4
PUBMED ID
DOI
10.1016/J.BMCL.2014.04.023
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
Q08881 ITK, EMT, LYK SPODOPTERA FRUGIPERDA HUMAN
INTERLEUKIN-2-INDUCIBLE T-CELL KINASE, IL-2-INDUCI ...
Mutations
Q08881 ITK, EMT, LYK SPODOPTERA FRUGIPERDA HUMAN
INTERLEUKIN-2-INDUCIBLE T-CELL KINASE, IL-2-INDUCI ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402