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3D Structure View

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GENERAL
TITLE
DISCOVERY AND OPTIMIZATION OF NEW BENZIMIDAZOLE- AND BENZOXAZOLE- PYRIMIDONE SELECTIVE PI3KBETA INHIBITORS FOR THE TREATMENT OF PHOSPHATASE AND TENSIN HOMOLOGUE (PTEN)-DEFICIENT CANCERS
DATE LAST MODIFIED
24 Apr 2019
RELEASE
16 May 2012
OBSOLETE
CLASSIFICATION
TRANSFERASE
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 1 21 1
RESOLUTION RANGE HIGH
2.8
RESOLUTION RANGE LOW
71.6
PUBMED ID
DOI
10.1021/JM300241B
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
O35904 -- SPODOPTERA FRUGIPERDA HOUSE MOUSE
PI3-KINASE SUBUNIT DELTA, PI3K-DELTA, PI3KDELTA, P ...
Mutations
O35904 -- SPODOPTERA FRUGIPERDA HOUSE MOUSE
PI3-KINASE SUBUNIT DELTA, PI3K-DELTA, PI3KDELTA, P ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402