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GENERAL
TITLE
DISCOVERY OF PYRROLIDINE-BASED B-SECRETASE INHIBITORS: LEAD ADVANCEMENT THROUGH CONFORMATIONAL DESIGN FOR MAINTENANCE OF LIGAND BINDING EFFICIENCY
DATE LAST MODIFIED
-
RELEASE
18 Jan 2012
OBSOLETE
CLASSIFICATION
HYDROLASE/HYDROLASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
C 2 2 21
RESOLUTION RANGE HIGH
1.9
RESOLUTION RANGE LOW
50
PUBMED ID
DOI
10.1016/J.BMCL.2011.11.024

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
P56817 BACE1, BACE, KIAA1149 -- HUMAN
BACE1, ASPARTYL PROTEASE 2, ASP2, ASP 2, BETA-SITE ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402