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GENERAL
TITLE
ALPHA-KETO-ALDEHYDE BINDING MECHANISM REVEALS A NOVEL LEAD STRUCTURE MOTIF FOR PROTEASOME INHIBITION
DATE LAST MODIFIED
24 Jan 2018
RELEASE
8 Jun 2011
OBSOLETE
CLASSIFICATION
HYDROLASE/HYDROLASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 1 21 1
RESOLUTION RANGE HIGH
2.7
RESOLUTION RANGE LOW
25
PUBMED ID
DOI
10.1002/ANIE.201005488
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
P30657 -- -- YEAST
MACROPAIN SUBUNIT PRE4, PROTEINASE YSCE SUBUNIT PR ...
Mutations
P38624 -- -- YEAST
MACROPAIN SUBUNIT PRE3, PROTEINASE YSCE SUBUNIT PR ...
Mutations
P23639 -- -- YEAST
MACROPAIN SUBUNIT Y7, PROTEINASE YSCE SUBUNIT 7,MU ...
Mutations
P23638 -- -- YEAST
MACROPAIN SUBUNIT Y13, PROTEINASE YSCE SUBUNIT 13, ...
Mutations
P40303 -- -- YEAST
MACROPAIN SUBUNIT PRE6, PROTEINASE YSCE SUBUNIT PR ...
Mutations
P32379 -- -- YEAST
MACROPAIN SUBUNIT PUP2, PROTEINASE YSCE SUBUNIT PU ...
Mutations
P40302 -- -- YEAST
MACROPAIN SUBUNIT PRE5, PROTEINASE YSCE SUBUNIT PR ...
Mutations
P21242 -- -- YEAST
MACROPAIN SUBUNIT C1, PROTEINASE YSCE SUBUNIT 1,MU ...
Mutations
P21243 -- -- YEAST
MACROPAIN SUBUNIT C7-ALPHA, PROTEINASE YSCE SUBUNI ...
Mutations
P25043 -- -- YEAST
MACROPAIN SUBUNIT PUP1, PROTEINASE YSCE SUBUNIT PU ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402