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GENERAL
TITLE
DESIGN, SYNTHESIS, BIOLOGICAL EVALUATION AND X-RAY CRYSTAL STRUCTURES OF NOVEL CLASSICAL 6,5,6-TRICYCLICBENZO[4,5]THIENO[2,3-D]PYRIMIDINES AS DUAL THYMIDYLATE SYNTHASE AND DIHYDROFOLATE REDUCTASE INHIBITORS
DATE LAST MODIFIED
8 Nov 2017
RELEASE
25 May 2011
OBSOLETE
CLASSIFICATION
OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
H 3
RESOLUTION RANGE HIGH
1.35
RESOLUTION RANGE LOW
53.22
PUBMED ID
DOI
10.1016/J.BMC.2011.03.067

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
P00374 DHFR, DHFRP1 ESCHERICHIA COLI HUMAN -- Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402