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GENERAL
TITLE
DISCOVERY OF AMINOHETEROCYCLES AS A NOVEL BETA-SECRETASE INHIBITOR CLASS
DATE LAST MODIFIED
1 Nov 2017
RELEASE
7 Jul 2009
OBSOLETE
CLASSIFICATION
HYDROLASE
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
C 1 2 1
RESOLUTION RANGE HIGH
2.7
RESOLUTION RANGE LOW
47.25
PUBMED ID
DOI
10.1016/J.BMCL.2009.04.033
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
P56817 BACE, BACE1, BETA-SECRETASE, KIAA1149 ESCHERICHIA COLI HUMAN
BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYM ...
Mutations
P56817 BACE, BACE1, BETA-SECRETASE, KIAA1149 ESCHERICHIA COLI HUMAN
BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYM ...
Mutations
P56817 BACE, BACE1, BETA-SECRETASE, KIAA1149 ESCHERICHIA COLI HUMAN
BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYM ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402