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Alpelisib
FEATURES
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NAMES
  • 1LT
  • Alpelisib
  • BYL-719
  • NVP-BYL719
  • PIQRAY
SMILES
Cc1nc(NC(=O)N2CCC[C@H]2C(N)=O)sc1-c1ccnc(C(C)(C)C(F)(F)F)c1
InChI
InChI=1S/C19H22F3N5O2S/c1-10-14(11-6-7-24-13(9-11)18(2,3)19(20,21)22)30-16(25-10)26-17(29)27-8-4-5-12(27)15(23)28/h6-7,9,12H,4-5,8H2,1-3H3,(H2,23,28)(H,25,26,29)/t12-/m0/s1
MOLECULAR FORMULA
C19H22F3N5O2S
CROSS REFERENCES

Alpelisib - target affinity plot

*Select a region to zoom

Alpelisib - target affinity table

ProteinProtein familyMean PotencyMost Potent ValueLeast Potent ValueSample count
PIK3CA PIK3CAPI3/PI4-kinase family. 24.66 nM 4.6 nM 74 nM 7
PIK3CG PIK3CGPI3/PI4-kinase family. 250 nM 250 nM 250 nM 3
PIK3CD PIK3CDPI3/PI4-kinase family. 654 nM 290 nM 1,200 nM 5
PIK3CB PIK3CBPI3/PI4-kinase family. 1,600 nM 1,200 nM 2,200 nM 5
Pik3cb Pik3cbPI3/PI4-kinase family. 2,200 nM 2,200 nM 2,200 nM 1
PRKDC PRKDCPI3/PI4-kinase family. 9,100 nM 9,100 nM 9,100 nM 1
ATR ATRPI3/PI4-kinase family. ATM subfamily. 9,100 nM 9,100 nM 9,100 nM 1
PIK3C3 PIK3C3PI3/PI4-kinase family. 9,100 nM 9,100 nM 9,100 nM 1
MTOR MTORPI3/PI4-kinase family. 9,100 nM 9,100 nM 9,100 nM 1
ATM ATMPI3/PI4-kinase family. ATM subfamily. 10,000 nM 10,000 nM 10,000 nM 1